- 作者: Todd L. Demmy Colette Wagner-Mann Alisha Allen
- 作者服務機構: Department of Surgery, University of Missouri-Columbia School of Medicine, Columbia, Mo., USA
- 中文摘要: --
- 英文摘要: the 30-min dwell time. The pulmonary circulation can beisolated by minimally invasive operative and cathetertechnology so that the pulmonary parenchyma can beexposed to a high concentration of a compound for atleast 30 min in the canine model.A pilot study was designed to determine the feasibility ofcombining minimally invasive surgery techniques andcardiac surgical catheter technology to deliver high-doseunilateral pulmonary chemotherapy. Single lung ventila-tion general anesthesia was combined with catheter-based left pulmonary artery (PA) control in 4 mongreldogs. p-Aminohippuric acid (PAH) was used to quantifyleakage of pulmonary arterial infusate. Surgical expo-sure was progressively less invasive. Dissection of crani-al and caudal pulmonary veins followed methods usedin minimally invasive pulmonary lobectomy. All animalssurvived the experimental procedure. The Heart-Port En-doplege catheter controlled the canine PA. A volume(50 cm ) of infusate much smaller than the calculatedpulmonary vascular volume caused less vascular over-distention and diffused throughout the pulmonary vas-cular bed within 3-5 min as verified by fluoroscopy. 75%of the tracer remained in the lung at the completion of
- 中文關鍵字: --
- 英文關鍵字: High-dose chemotherapy, Lung perfusion, Pulmonary metastases, Selective lung perfusion, Video-assisted thoracic surgery