• 作者： 丁汶谷; 郭邦康
• 作者服務機構： 國防醫學院生物化學系
• 中文摘要： A growth inhibitory substance, G3, can inhibits protein synthesis of a cancercell line, H. Ep-2 cell. We found that the inhibitory effect on DNA synthesis ismore potent than RNA synthesis. By using SH compounds (cysteine and glutathione) as antagonistic agent to G3, we found that protein and RNA syntheses wereboth partialy recovered, but not the DNA synthesis. It is assumed that the inhibitory effect of G3 on protein and RNA synthesesare more directly related to inhibition of SH enzymes. While the inhibition onDNA synthesis might be due to prevention of DNA replication by abnormal bindingbetween G3 and double-stranded DNA.
• 英文摘要： --
• 中文關鍵字： --
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