- 作者: Szokan, Gy. ; Almas, M. ; Kotai, A. et al.
- 作者服務機構: Dept. of Organic Chemistry, Eotvos Univ., Budapest, Hungary
- 中文摘要: Benzyloxycarbonyl-glutamylpeptide p-nitrophenylesters were prepared from protected amino acids, e.g.: p- nitrophenyl-glutamate as carboxyl component and aminoacid or peptide p-nitrophenylesters as amino components by different kinds of peptide coupling methods. Mixed carbonic anhydride and azide methods gave good results. The p- nitrophenylesters existed as temporary protecting groups, so the peptide couplings proceeded together with simultaneous activation. The conditions and applications of the procedure are discussed. The peptides having one or more active ester groups were used to form amides by their aminolysis with derivatives of ethylamine or were polycondensated (after deprotection) to obtain polypeptides.
- 英文摘要: --
- 中文關鍵字: Temporarily Protecting Group; Nitrophenyl Active Ester; Simultaneous Activation; Peptide Synthesis; Polyactive Ester
- 英文關鍵字: 暫時保護基;硝基酚活性酯;同步活化;胜□合成;聚活性酯