- 作者: Bing Cheng, Qiang Yu & Wenyu Wang
- 作者服務機構: 1.Cancer and Stem Cell Biology, DUKE-NUS Graduate Medical School of Singapore, Singapore, Singapore 2.Cancer Precision Medicine, Genome Institute of Singapore, Agency for Science, Technology, and Research, Biopolis, Singapore 3.Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 4.Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China 5.Guangdong Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- 中文摘要:
- 英文摘要:
Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the view of cancer as a
tumor cell-centric disease. The tumor microenvironment, especially termed the "seed and soil" theory, has emerged
as the key determinant in cancer development and therapeutic resistance. The TME mainly consists of tumor cells,
stromal cells such as fbroblasts, immune cells, and other noncellular components. Within the TME, intimate communications among these components largely determine the fate of the tumor. The pivotal roles of the stroma, especially
cancer-associated fbroblasts (CAFs), the most common component within the TME, have been revealed in tumorigenesis, tumor progression, therapeutic response, and tumor immunity. A better understanding of the function of
the TME sheds light on tumor therapy. In this review, we summarize the emerging understanding of stromal factors,
especially CAFs, in cancer progression, drug resistance, and tumor immunity with an emphasis on their functions in
epigenetic regulation. Moreover, the importance of epigenetic regulation in reshaping the TME and the basic biological principles underpinning the synergy between epigenetic therapy and immunotherapy will be further discussed. - 中文關鍵字:
- 英文關鍵字: Tumor microenvironment, Cancer-associated fbroblast, Epigenetic regulation, Immunotherapy