- 作者: Maryam Hajiabbas, Claudia D’Agostino, Julia Simińska-Stanny, Simon D. Tran, Amin Shavandi & Christine Delporte
- 作者服務機構: 1.3BIO-BioMatter, École Polytechnique de Bruxelles, Université Libre de Bruxelles, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050, Brussels, Belgium 2.Department of Process Engineering and Technology of Polymer and Carbon Materials, Faculty of Chemistry, Wroclaw University of Science and Technology, Norwida 4/6, 50-373, Wroclaw, Poland 3.Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, Blg G/E CP 611, B-1070, Brussels, Belgium 4.McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, H3A 0C7, Canada
- 中文摘要:
- 英文摘要:
Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for
head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strategies have been consid‑
ered for SG regeneration, repair, or whole organ replacement. An in-depth understanding of the development and
diferentiation of epithelial stem and progenitor cells niche during SG branching morphogenesis and signaling path‑
ways involved in cell–cell communication constitute a prerequisite to the development of suitable bioengineering
solutions. This review summarizes the essential bioengineering features to be considered to fabricate an engineered
functional SG model using various cell types, biomaterials, active agents, and matrix fabrication methods. Further‑
more, recent innovative and promising approaches to engineering SG models are described. Finally, this review
discusses the diferent challenges and future perspectives in SG bioengineering. - 中文關鍵字:
- 英文關鍵字: Salivary gland, Tissue engineering, Biomaterial, Cell culture models, Xerostomia