- 作者: Nadeem Siddiqui, Mashooq A. Bhat, Suroor A. Khan, Waquar Ahsan and M. Shamsher Alam
- 作者服務機構: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, India
- 中文摘要: A series of coumarin incorporated Schiff bases of 1,3,4-oxadiazoles (1-18) was synthesized. The structures of the synthesized compounds were confirmed on the basis of spectral data and elemental analysis. The anticonvulsant and neurotoxicity was studied by maximal electroshock seizure (MES) and rotorod method, respectively. A majority of the compounds were active in MES test. All the compounds were less neurotoxic than the standard drug phenytoin.
- 英文摘要: --
- 中文關鍵字: Coumarin; MES test; 1,3,4-Oxadiazoles; Schiff bases.
- 英文關鍵字: --