- 作者: 陳基旺 ; 林國森 ; 陳建樹
- 作者服務機構: 國防醫學院藥理研究所
- 中文摘要: To measure the hydrophobic character of the ribose moiety of doridosine on the adenosine receptors, 2',3'-didehydro-2',3'-dideoxydoridosine (2) and 2',3'-dideoxydoridosine (3) were prepared. Initial treatment of doridosine with N,N-dimethylformamide diethylacetal, and subsequently with tert-butyldimethylsilyl chloride gave 5. Compound 5 was then reacted with 1,1'-thiocarbonyldiimidazole and the resulting thionocarbonate 6 was heated with triethyl phosphite at 135.degree.C to afford 7. Treatment of compound 7 with tetrabutylammonium fluoride and methanolic ammonia furnished compound 2 in good yield. Compound 2 was subjected to catalytic hydrogenation affording compound 3 in 85% yield.
- 英文摘要: --
- 中文關鍵字: 1-Methylisoguanosine; 2',3'-Didehydro-2',3'-Dideoxy-1-Methylisoguanosine; 2',3'-Dideoxy-1-Methylisoguanosine; Adenosine
- 英文關鍵字: 1-甲基異鳥;2';3'-二去氫-2';3'-二去氧-1-甲基異鳥;2';3'-二去氧-1-甲基異鳥;腺酸