- 作者: 王光燦
- 作者服務機構: 中央研究院生物化學研究所籌備處
- 中文摘要: 第一部;蛇神經毒羧基端六聚?的合成。蛇(Naja naja atra)神經毒Cobrotoxin的羧基端六聚?以液相法逐步合成完成。其六聚?為NPS-Thr-Asp(OBzI)-Arg(Tos)-Cys(Bzl)-Asn-Asn-OTMB。第二部;蛇心臟毒的化學合成“以Merrifield的固相合成法合成60個胺基酸的心臟毒(Cardiotoxin)。是利用DCCI把60個胺基酸縮合於樹脂。目前進行脫離反應。 有關上述合成過程中,已合成40種胺基酸衍生物和19種聚?中間體。
- 英文摘要: Part I. Synthesis of neurotoxin carboxyl terminal hexapeptide.The chemical synthesis of carboxyl terminal hexapeptide of neurotoxic snakevenom (Naja naja atra) cobrotoxin was done by stepwise coupling on liquidphase. The protected hexapeptide are Nps-Thr-Asp (OBzI)-Arg(Tos)-Cys(Bzl)-Asn-Asn-OTMB.Part II. Synthesis of cardiotoxinThe synthesis of cardiotoxin was done by solid phase synthesis of Merrifield.Sixty amino acids were coupled to resin. Deblocking from resin are inprogress. We have synthesis amino acids derivatives and peptides interme-diates.
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