- 作者: Li Jinlian; Zhou Yingbin; Wang Chunbo
- 作者服務機構: Medical College, Qingdao University, 422 Room, Boya Building, 308 Ningxia Road, Qingdao, 266071, China
- 中文摘要: --
- 英文摘要: Solar ultraviolet (UV) radiation is a major environmental factor that causes DNA damage, inflammation, erythema, sunburn, immunosuppression, photoaging, gene mutations, and skin cancer. p38 mitogen activated protein kinase (MAPK) are strongly activated by UV radiation, and play important roles in regulating cellular responses to UV. In this review, we examine the role played by p38 MAPK in mediating UV-induced cell cycle, apoptosis, inflammation, and skin tanning response. We review the role played by p38 MAPK in transcriptional regulation of key downstream genes that have been implicated in the regulation of cellular responses to UV radiation. Understanding this will undoubtedly help in the prevention and control of UV-induced damage and the development of novel therapeutic strategies.
- 中文關鍵字: --
- 英文關鍵字: cellular response, p38 mitogen activated protein kinase (MAPK), ultraviolet radiation