- 作者: Raul Teruel, Irene Martinez-Martinez, Jose A Guerrero, Rocio Gonzalez-Conejero, Maria E de la Morena-Barrio, Salam Salloum-Asfar, Ana B Arroyo, Sonia Aguila, Nuria Garcia-Barbera, Antonia Minano, Vicente Vicente, Javier Corral and Constantino Martinez*
- 作者服務機構: Centro Regional de Hemodonacion, University of Murcia, IMIB, Spain, C/Ronda de Garay S/N, 30003, Murcia, Spain
- 中文摘要: --
- 英文摘要:
Background: Developmental haemostatic studies may help identifying new elements involved in the control of key haemostatic proteins like antithrombin, the most relevant endogenous anticoagulant.
Results: In this study, we showed a significant reduction of sialic acid content in neonatal antithrombin compared with adult antithrombin in mice. mRNA levels of St3gal3 and St3gal4, two sialyltransferases potentially involved in antithrombin sialylation, were 85% lower in neonates in comparison with adults. In silico analysis of miRNAs overexpressed in neonates revealed that mir-200a might target these sialyltransferases. Moreover, in vitro studies in murine primary hepatocytes sustain this potential control.
Conclusions: These data suggest that in addition to the direct protein regulation, microRNAs may also modulate qualitative traits of selected proteins by an indirect control of post-translational processes. - 中文關鍵字: --
- 英文關鍵字: --