- 作者: 姜宏哲; 姚介民; 黃克?
- 作者服務機構: 國立臺灣師範大學化學研究所; 靜宜女子文理學院化學系
- 中文摘要:
本文敘述磺胺劑之?及亞硝基?衍生物之合成方法,取用之磺胺劑有短效型之磺胺甲噁唑、磺胺異噁唑、磺胺二
甲嘧啶以及長效型之磺胺甲氧噠嗉。合成之新化合物計有N-甲基?衍生物3個,N-2-氯乙基?衍生物4個,N-
甲基亞硝基?衍生物3個以及N-2-氯乙基亞硝基?衍生物4個,以上14個新衍生物擬提供作抗癌試驗。n - 英文摘要: The synthesis of three N-Methylurea, three N-Methyl-N-nitrosourea, four N-(2-Chloroethyl)ureaand four N-(2-Chloroethyl)-N-nitrosourea analogues of sulfa drugs as potential antineoplastic agents isdescribed. Sulfa drugs taken as carriers are sulfamethoxazole(1), sulfamethoxypyridazine(2), sulfametha-zine(3), and sulfisoxazole(4), respectively. Among those carriers, 1, 3, and 4 are short-acting sulfa drugswhile 2 is a long-acting type. All of the derivatives in this report are new compounds and will be tested toevaluate their anticancer activity.
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- 英文關鍵字: --