- 作者: Sabah Haq, Jensine Grondin, Suhrid Banskota and Waliul I. Khan
- 作者服務機構: 1. Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada 2. Department of Pathology and Molecular Medicine, McMaster University, Room 3N7, Hamilton, ON L8N 3Z5, Canada
- 中文摘要:
- 英文摘要:
The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In the intestine, a complex interplay between the microbiota, epithelial barrier and the local immune system maintains homeostasis and promotes a healthy gut. One of the major cellular catabolic processes that regulate this homeostasis is autophagy. Autophagy is required to maintain anti-microbial defense, epithelial barrier integrity and mucosal immune response. Dysregulation of the autophagy process causes disruption of several aspects of the intestinal epithelium and the immune system that can lead to an inappropriate immune response and subsequent inflammation. Genome-wide association studies have found an association between several risk loci in autophagy genes and inflammatory bowel disease. The aim of the current review is to provide an update on the role of autophagy in intestinal mucosal physiology and in the control of inappropriate inflammation. - 中文關鍵字:
- 英文關鍵字: Autophagy, Intestinal mucosa, Epithelium, Immune response, Inflammation, Microbiota