- 作者: Xuemei Zhang, Chao Wang, Guangyao Song, Kexin Gan, Dexian Kong, Qian Nie and Luping Ren
- 作者服務機構: Hebei Medical University, Shijiazhuang 050030, Hebei, China
- 中文摘要: --
- 英文摘要:
Background: Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remains to be elucidated.
Results: A high-fat diet resulted in insulin resistance as well as accumulation of cytosolic lipid intermediates and down-regulation of MFN2 and CPT1 in skeletal muscle in rats, while MFN2 overexpression improved insulin sensitivity and reduced lipid intermediates in muscle, possibly by upregulation of CPT1 expression.
Conclusions: MFN2 overexpression can rescue insulin resistance, possibly by upregulating CPT1 expression leading to reduction in the accumulation of lipid intermediates in skeletal muscle. These observations contribute to the investigations of new diabetes therapies. - 中文關鍵字: --
- 英文關鍵字: Mitofusion2, Insulin resistance, Skeletal musle, Lipid intermediates, CPT1, CD36