- 作者: --
- 作者服務機構: Analytical Chemistry Department, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
- 中文摘要: A new simple extractive spectrophotometric method has been developed for the determination of levofloxacin (I), norfloxacin (II), and ciprofloxacin (III) in pure form and tablets. The method is based on the formation of blue-colored ion-pair associates between the drugs and the inorganic complex, cobalt (II) thiocyanate, at pH 2.5. Those ion-pair associates are readily extracted into an n-butanol-dichloromethane solvent mixture (3.5:6.5) and determined spectrophotometrically at 623 nm. The concentration range is 20-240 mg mL-1 for the three studied drugs. The proposed method was successfully applied to determine these drugs in their tablet formulations, and the results are in good agreement with those obtained by the reference methods.
- 英文摘要: --
- 中文關鍵字: Spectrophotometry; Cobalt thiocyanate; Levofloxacin; Norfloxacin; Ciprofloxacin; Ion-pair; Pharmaceutical analysis.
- 英文關鍵字: --