- 作者: Lucas Pagura, Juan Manuel Caceres, Albertina Cardinale, Olga Graciela charovsky, Ricardo Jose Di Masso, Mariano Federico Zacarias-Fluck, Maria Jose Rico ,Viviana Rosa Rozados
- 作者服務機構: Instituto de Genetica Experimental, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe Rosario, Argentina
- 中文摘要: --
- 英文摘要:
Background:
Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune system throughout tumor development. Animal models are useful tools for studying diseases such as cancer. The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi? and CBi/L inbred mice lines.
Results:
The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. CBi/L and CBi? mice were artificially selected for body conformation from CBi. When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi? the tumor growths briefly and then begins a rejection process in 100% of the animals. In CBi/L the growth of the tumor shows the three phases: 51.6% in ES, 18.5% in EQ and 29.8% in EL.
Conclusions:
The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi? and CBi/L, is a good murine model to study the process of tumor immunoediting. - 中文關鍵字: --
- 英文關鍵字: Cancer immunoediting, Murine models, Mammary adenocarcinoma, Mathematical model