第6卷‧第4期,
198210
, pp. 493-497
卵巢切除降低大白鼠血清高密度脂蛋白之研究
- 作者：
蔡文芷; 沈明琛; 陳敦; 李詩慶
- 作者服務機構：
三軍總醫院醫學研究部; 國防醫學院生化系
- 中文摘要：
以超高速離心分離怯分析比較雌雄大白鼠血清脂蛋白之組成。將飼養六個星期大之大白鼠分為三組：以去除卵巢之雌鼠為實驗組，對照組之雌鼠亦進行開刀手術但僅除去微量脂肪體；並取雄鼠為對照比較。手術十三個月後，將動物犧牲；取血清利用超高速離心連續分離法離心後，測定血清脂蛋白各組成之濃度。結果顯示對照組雌鼠血清中高密度脂蛋白（HDL）之值較雄鼠為高；而去卵巢雌鼠血清高密度脂蛋白濃度則較對照組雌鼠有顯著下降。此結果指示，雌性激素對大白鼠血清中高密度脂蛋白有增加之作用；惟各種性激素對血清脂蛋白組成之特定作用仍待進一步研究。
- 英文摘要：
Serum lipoproteins and their compositions in the rat were studied by sequential ultracentrifugation.Experimental rats, Sprague-Dawley strain, were ovariectomized when they were 6 weeks old. Controlfemale rats were sham operated, and control male rats were included in the study. Animals were sacrificed13 months after operation. The results demonstrated that the female control rats had the highest highdensity lipoprotein (HDL) level, and the male controls had the lowest HDL concentration in the serum.Ovariectomy significantly reduced the HDL level.
- 中文關鍵字：
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- 英文關鍵字：
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