- 作者: Yufei Xu; Guoxing Song
- 作者服務機構: Department of Biophysics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
- 中文摘要: --
- 英文摘要: CD40, a member of the nerve growth factor/tumor necro-sis factor receptor superfamily, and its ligand, CD154,play essential roles in cell immune responses. The re-suits of many studies have indicated that CD40-CD154interaction can upregulate costimulatory molecules, acti-vate antigen-presenting cells (APCs), influence T-cellpriming and T-cell-mediated effector functions as well asparticipate in the pathogenic processing of chronic in-flammatory diseases, such as autoimmune diabetes,graft rejection, atherosclerosis, and cancer. Ligation ofCD40 on cancer cells was also found to produce a directgrowth-inhibitory effect through cell cycle blockage and/or apoptosis with no overt side effects on normal cellsand treatment with CD154 can heighten tumor rejectionimmune response as well. However, systemic treatmentwith CD154 has some potential risks. Therefore, search-ing for efficient and safe strategies of CD154-based can-cer therapy has been a hot topic in human cancerresearch. This review focuses on the latest discoveredfunctions of CD40-CD154 interaction in cell immune re-sponses and on the newfindings of CD154-based humancancer therapy.
- 中文關鍵字: --
- 英文關鍵字: --