- 作者: Anshu Dandia*, Ruby Singh, Harshita Sachdeva, Rajive Gupta and Satya Paul
- 作者服務機構: Department of Chemistry, University of Rajasthan, Jaipur-302 004, India
- 中文摘要:
Spiro[indole-pyranoimidazoles] (5) and spiro[indole-pyranobenzopyrans] (6) are readily synthesized in one step in 86-92 and 91-97% yields by the Michael condensation of 3-dicyanomethylene-2H-indol-2-ones (2) with 1-phenyl-2-thiohydantoin (3) and 4-hydroxy-2H-1-benzopyran-2-one (4), respectively, without using any catalyst under different reaction conditions (conventional heating and microwave irradiation using (a) polar solvents (b) neutral alumina/silica gel as inorganic solid support in solvent free conditions). 2 was synthesized in situ by the Knoevenagel condensation of indole-2,3-dione (1) and malononitrile in the absence of any catalyst.
100% conversion was observed in most cases on TLC which also showed the formation of a single product. The comparison between the various methods is established. - 英文摘要: --
- 中文關鍵字: Indole-2,3-diones; 3-Dicyanomethylene-2H-indole-2-ones; 1-Phenyl-2-thiohydantion; 4-Hydroxy-2H-1-benzopyran-2-one; 3-Spiroindolines; Microwave irradiation.
- 英文關鍵字: Indole-2,3-diones; 3-Dicyanomethylene-2H-indole-2-ones; 1-Phenyl-2-thiohydantion; 4-Hydroxy-2H-1-benzopyran-2-one; 3-Spiroindolines; Microwave irradiation.