• 作者： 呂鋒洲
• 作者服務機構： 國立臺灣大學醫學院生化研究所
• 中文摘要： 著者發現嘉南烏腳病患區飲用地下水含有藍綠色螢光物質。並且證明藍綠色螢光物質是有機化合物，它具有造成雞胚胎畸型發育之毒性。有些藍綠色螢光物質可能是麥角生物鹼而有些是類似維生素D 之物質。 著者從文獻上引證麥角生物鹼中毒以及維生素D 中毒後所引起之症狀與烏腳病患者之症狀有許多相似處，因此認為除砷中毒因素外麥角生物鹼及維生素D 中毒可能與病因有密切關係。
• 英文摘要： Blackfoot distase is an endemic peripheralvascular disease found on the south-west coastof Taiwan. Extensive epidemiological studieshave disclosed that the high arsenic content inthe drinking water from artesian wells is themost plausible causal factor for the occurrenceof Blackfoot disease in these areas. Recently, we have studied toxic compoundsin artesian well water in thr endemic Blackfootdisease areas (Chic-i and Tainan Counties）, wefound that the artesian well water of these areasshows strong blue-green fluorescence under longU.V. light irradiation. The intensity of blue-green fluorescence revealed some relationshipswith the occurrence and Incidence of the disease.We also found that fluorescent compounds indrinking water in artesian well of Blackfootendemic areas caused teratogenic toxicity ofchick enbryos. We have identified that some offluorescent compounds are ergot alkaloids andsome are ergocalciferol relative compounds. After we compared symptoms of hypervita-minosis D and ergotism with those of Blackfootdisease, we found that they have similarities inmany respects. Therefore, we suggest that inaddition to arsenic poisoning, ergot alkaloids andVitamin D in the artesian well water may haverelation to the causes of Blackfoot disease.
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