• 作者： 彭志綱
• 作者服務機構： Schhol of Dentistry; Natio nal Defense Medical Center and Department of Dentistry; Tri-Service General Hospital
• 中文摘要： 本研究係利用?免疫法研討牙周病患者對膠原蛋白之血清IgG抗體，不同型（嚴重性）牙周病包括牙齦炎，年輕型牙
  周炎，成人型牙周炎與正常人相比較。結果顯示年輕型牙周炎患者對自然的第一、三型膠原蛋白之平均血清IgG抗體比
  正常人為有意義的高。而牙齦炎或成人型牙周炎與正常人相比較則沒有顯著的差別。但是年輕型或成人型牙周炎患者對
  變性的第一、三型膠原蛋白之平均血清IgG抗體比正常人為有意義的高。而牙齦炎患者與正常人相比較則沒有差異。這
  些發現顯示牙周病患者對自然的與變性的第一或第三型膠原蛋白抗體的產生與牙周病之型別或嚴重性有關，特別是重度
  的牙周組織破壞。a
• 英文摘要： Serum IgG antibodies to collagen were investigated by using enzyme linked immunosorbent assay(ELISA) in patients with chronic periodontal disease. Patients with varying forms of periodontal diseaseincluding gingivitis, juvenile periodontitis, and adult periodontitis were compared with the normal subjects.The mean serum IgG levels of ELISA antibodies to native type Ⅰ or Ⅲ collagen in patients with juvenileperiodontitis were significantly higher than those of the normal subjects, but no difference was foundbetween the patients with either gingivitis or adult periodontitis and the normal subjects. In addition,the mean serum IgG levels of ELISA antibodies to denatured type Ⅰ or Ⅲ collagen in patients with juvenileor adult periodontitis were significantly higher than those of the normal subjects. These findings suggestthat antibodies to native and denatured type Ⅰ or Ⅲ collagen may be associated with different formsor severities of periodontal disease, especially advanced periodontal destruction.
• 中文關鍵字： antibody; collagen; periodontal disease
• 英文關鍵字： --