- 作者： 陳俊嘉；王聖賢；李發耀；蔡世豪；吳淑玲；盧瑞華；張扶陽；李壽東
- 中文摘要： The findings related to the effects of somatostatin and octreotide in experimental and clinical acute pancreatitis are so far inconclusive. In this study, we examined the early effects of prophylactic octreotide in acute experimental pancreatitis. Serum levels of amylase and lipase, pancreatic histopathology and systemic hemodynamic profiles, including mean arterial pressure, cardiac index, systemic vascular resistance and heart rate, were evaluated 5 hours after glycodeoxycholic acid (GDOC) or sodium taurodeoxycholate (TDC)-induced pancreatitis with or without prophylactic octreotide (10 .mu.g/Kg) in rats. GDOC and TDC induced mild and severe pancreatitis, respectively. Octreotide significantly reduced serum levels of amylase and lipase at 5 hours in GDOC and TDC-induced pancreatitis. Octreotide significantly reduced the severity of pancreatic edema, necrosis and hemorrhage in TDC-induced pancreatitis. In addition, hemodynamic shock in TDC-induced pancreatitis was improved significantly by the administration of octreotide (mean arterial pressure 70.3 .plmin.7.7 vs. 95.0 .plmin.3.5 mmHg, p < 0.05; cardiac index 16.7 .plmin.2.5 vs. 24.0 .plmin.5.1 ml *min/sup -1/ *100 g/sup -1/, p < 0.05 ). However, octreotide did not show significant beneficial effect in pancreatic histopathology and hemodynamics in GDOC-induced pancreatitis. Thus we conclude that prophylactic octreotide improves pancreatic histopathology and hemodynamic shock in TDC-induced pancreatitis.
- 英文摘要： --
- 中文關鍵字： acute pancreatitis, hemodynamics, histopathology, octreotide, rat
- 英文關鍵字： --
