• 作者： 洪啟賦; 林國瑞; 李全森
• 作者服務機構： 中國醫藥學院附設醫院外科
• 中文摘要： Ethylenethiourea（ETU）是Zineb及Maneb等殺黴菌劑的分解物，此類殺黴菌劑常用在穀類及水果的噴灑，故食物中常有污染。Khera於毒物學中報告ETU可致懷孕大白鼠胎兒各種器官的先天性畸型。 為了解中樞神經系統先天性畸型的致畸型機轉，以單劑量60 mg /Kg，120 mg / Kg，240 mg/Kg的ETU給予不同懷孕日期的SD大白鼠經胃灌食，來誘發大白鼠胎兒中樞神經系統先天性畸型。結果胎兒中樞神經系統先天性畸型較用try-pan blue，salicylate等方法的發生率高且其畸型依懷孕日期不同有特定的類型如腦膜膨出症，露腦、小腦症、水腦症、腦水症及脊椎二分裂等畸型。 本實驗誘發的中樞神經系統先天性畸型與人類中樞神經系統先天性畸型極為相似，在醫學上是相當有興趣的，故用單劑量ETU給予懷孕大白鼠經胃灌食是一種簡單而有價值的方法誘發各種類型中樞神經系統先天性畸型的動物模型，供以基礎及臨床醫學對中樞神經系統先天性畸型的研究。
• 英文摘要： Ethylenethiourea (ETU) is a degradation product from ethylenebisdithiocarbamate such as Zineband Maneb which have been extensively used in food crops and ornamental plants. Khera (1973,1975,1977) reported that administration of ETU to pregnant rats could induce anomalies in the visceral organsand the central nervous system of fetuses in food toxicology. From this point, in an attempt to betterunderstand the pathomechanism of teratogenesis in the central nervous system, we have studied the effectsof ETU on the central nervous system of rat fetuses. In this study, pregnant Sprague Dawley (SD) rats were used and subjected to ETU. Various types ofcongenital malformations of the central nervous system are presented in rat fetuses including spinal dysra-phism associated with hindbrain crowding, exencephaly, meningoencephalocele, microencephaly, hydraen-cephaly and hydrocephalus. Each depended on the gestation days of the ETU administration and dosages.
• 中文關鍵字： spinal dysraphism; hindbrain crowding; ethylenethiourea; exencephaly
• 英文關鍵字： --