- 作者: Wrona, Monika Z. ; Zhang, Fa ; Dryhurst, Glenn
- 作者服務機構: Dept. of Chemistry and Biochemistry, Univ. of Oklahoma, Norman, Oklahoma, U.S.A.
- 中文摘要: The serotonergic neurotransmitter 5-hydroxytryptamine(5-HT), the catecholaminergic neurotransmitter dopamine (DA) and various tetrahydroisoquinoline (TIQ) and tetrahydro-.beta.-carboline (TH.beta.C) alkaloids are all easily oxidized compounds. Aberrant oxidative transformations of 5- HT and other central indoles might be involved in neurodegenerative Alzheimer's Disease (AD). Changes in the oxidation chemistry of DA appear to be fundamental in substantia nigra neurons in Parkinson's Disease (PD). Various TIQ and TH.beta.C alkaloids are elevated in the brain as a result of ethanol drinking. Recent studies into the electrochemical oxidation chemistry of 5-HT, DA and various TIQ and TH.beta.C alkaloids have been reviewed. The potential roles of the oxidation chemistry of these compounds in neurodegenerative AD, PD and alcoholism are discussed.
- 英文摘要: --
- 中文關鍵字: Alcoholism; Alzheimer's Disease; Dopamine; Hydroxytryptamine; Parkinson's Disease; Serotonin; Tetrahydroisoquinoline; Carbolines
- 英文關鍵字: 酒精中毒;阿耳滋海默氏病;多巴胺;羥基色胺;帕金森氏病;四氫異;類