• 作者： 林信男; 張文昌; 呂敏中
• 作者服務機構： 國立成功大學醫學院泌尿學科; 國立成功大學醫學院藥理學科; 國立成功大學醫學院附設醫院泌尿部
• 中文摘要： 陰莖勃起時血液黏稠度增加會使血管老化，最後導致動脈性陽萎之產生。本篇是探討心因性及動脈性陽萎病患接受陰莖海綿體內注射罌粟鹼混合酚特胺或前列腺素成一型後其陰莖血液中thromboxane B2及6-keto-prostaglandin Flα之相互關係。結果顯示病患陰莖血液中之thromboxane B2濃度沒有任何改變。反之，陰莖血液中6-keto-prostagl-andin Flα明顯有意義之增加，同時在同一位病患接受陰莖海綿體內注射罌粟鹼混合酣特肢後，其prostacyclin與thromboxane A2之比值明顯低於接受前列腺素成一型。初期結果顯示陰莖血液之prostacyclin可能參與動脈性陽萎及陰莖持久性勃起之發生機轉。
• 英文摘要： Penile hypercoagulability during erection may predispose to aging vascular changes and, eventually,arteriogenic impotence. The relationship of penile blood thromboxane B2 and 6-keto-prostaglandin Flαin both psychogenically and arteriogenically impotent patients after intracavernosal treatment with papaverineplus phentolamine or prostaglandin E1 was evaluated. No significant change in penile blood thromboxaneB2 was observed with treatment of these vasoactive drugs. On the other hand, penile blood 6-keto-pro-staglandin Flα was significantly increased with the injection of 30 mg of papaverine plus 0.5 mg of phento-lamine, and of 20 μg prostaglandin E1. Furthermore, the prostacyclin-to-thromboxane A2 ratio for thepatient who received papaverine plus phentolamine was significantly lower than that for the same individualreceiving prostaglandin E1. Our preliminary findings suggest that penile blood prostacyclin may participatein the pathogenesis of arteriogenic impotence and priapism.
• 中文關鍵字： thromboxane B2; 6-keto-prostaglandin Flα; arteriogenic impotence; vasoactive drugs
• 英文關鍵字： --