- 作者: Jing-Yi Lin; Tzu-Chun Chen; Kuo-Feng Weng; Shih-Cheng Chang; Li-Lien Chen; Shin-Ru Shih
- 作者服務機構: 1Research Center for Emerging Viral Infections, Chang Gung University, Tao-Yuan, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For
instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis,
acute flaccid paralysis, acute hemorrhagic conjunctivitis, severe neurological complications,
including brainstem encephalitis, meningitis and poliomyelitis, and even death. The interaction
between the virus and the host is important for viral replication, virulence and pathogenicity. This
article reviews studies of the functions of viral and host factors that are involved in the life cycle of
picornavirus. The interactions of viral capsid proteins with host cell receptors is discussed first, and
the mechanisms by which the viral and host cell factors are involved in viral replication, viral
translation and the switch from translation to RNA replication are then addressed. Understanding
how cellular proteins interact with viral RNA or viral proteins, as well as the roles of each in viral
infection, will provide insights for the design of novel antiviral agents based on these interactions. - 中文關鍵字: --
- 英文關鍵字: --