- 作者: Tong Chen, Shaoyu Tu, Ling Ding, Meilin Jin, Huanchun Chen & Hongbo Zhou
- 作者服務機構: 1.Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430030, China 2.State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430030, China
- 中文摘要:
- 英文摘要:
Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral functions during a viral invasion. However, co-evolution and co-adaptation between viruses and autophagy have armed viruses with multiple
strategies to subvert the autophagic machinery and counteract cellular antiviral responses. Specifcally, the host cell
quickly initiates the autophagy to degrade virus particles or virus components upon a viral infection, while cooperating with anti-viral interferon response to inhibit the virus replication. Degraded virus-derived antigens can be
presented to T lymphocytes to orchestrate the adaptive immune response. Nevertheless, some viruses have evolved
the ability to inhibit autophagy in order to evade degradation and immune responses. Others induce autophagy, but
then hijack autophagosomes as a replication site, or hijack the secretion autophagy pathway to promote maturation
and egress of virus particles, thereby increasing replication and transmission efciency. Interestingly, diferent viruses
have unique strategies to counteract diferent types of selective autophagy, such as exploiting autophagy to regulate
organelle degradation, metabolic processes, and immune responses. In short, this review focuses on the interaction
between autophagy and viruses, explaining how autophagy serves multiple roles in viral infection, with either proviral
or antiviral functions. - 中文關鍵字:
- 英文關鍵字: Autophagy degradation, Immune response, Selective autophagy, Viral infection, Viral replication