- 作者: 陳敦; 李詩慶; 蔡文芷; 丁予安; 李有柄
- 作者服務機構: 三軍總醫院醫學研究部; 三軍總醫院內科部
- 中文摘要:
為瞭解卵磷脂-?固醇醯基轉移?(LCAT)之活性與血漿脂質代謝的關係,我們檢測了健康國人以及冠狀動脈心
臟病和糖尿病患者的血漿脂質濃度與LCAT活性之變化。以170位20歲左右的年青人和49位年齡超過50歲的健康國人
分別為第一、第二對照組,並檢測19位心肌梗塞患者,39位心絞痛患者與26位糖尿病患者。結果顯示健康的青年人與年
老者的LCAT活性,分別為78±23與130±38 nmole/ml/h,以百分比活性表示時則分別為9.14±2.19與8.74±1.99%h。
心肌梗塞和心絞痛患者的LCAT 活性偏低(P<0.1),而適度控制的糖尿病患者,其LCAT百分比活性與健康的年老者
相近。LCAT活性與血漿中?固醇、游離?固醇、磷脂及低密度脂蛋白中?固醇之值,不論在正常人或冠狀動脈心臟
病患者均呈有意義的正相關性,其中尤以游離?固醇之相關性最為顯著。
a - 英文摘要: Lecithin:Cholesterol acyltransferase (LCAT) activity in the plasma and plasma concentrations oftotal cholesterol, unesterified cholesterol, triglyceride, phospholipid and lipoproteins were determined in170 young males, 49 old males, 19 cases of myocardial infarction, 39 cases of angina pectoris and 26 casesof diabetes mellitus. Our results showed that the molar LCAT activities of the normal young and oldmales were 98 ± 23 and 130 ±38 nmole/ml/h, respectively, and the fractional LCAT activities were 9.14 ±2.19 and 8.74 ± 1.99 %/h, respectively. Patients with myocardial infarction and agina pectoris tended tohave slightly lower molar and fractional LCAT activities (p<0.1), and the moderately well controlleddiabetics showed a similar fractional LCAT activity as that of the old healthy males. The LCAT activitywas consistently and significantly correlated to the plasma concentration of unesterified cholesterol.
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