- 作者: Lung-Ji Chang; Yi-Ming A. Chen; Mao-Yuan Chen; Chen-Cheng Chou; Shiing-Jer Twu; Li-Min Huang
- 作者服務機構: a Glaxo Heritage Research Institute and; Department of Medical Microbiology and; Infectious Diseases, University of Alberta; Edmonton, Canada;; b Institute of Public Health, National Yang-Ming University, c Department of Internal Medicine, College; of Medicine, National Taiwan University, d Department of Pediatrics, College of; Medicine, National Taiwan University, and; e Institute of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China
- 中文摘要: --
- 英文摘要: A wide variety of up-to-date results and knowledge were presented at the 10th International AIDS Meeting, Yokohama. Epidemiologically, most interest was focused on the discovery of a new HIV subtype O, which cannot be relia- bly detected by currently available ELISA kits. Clinically, it is gradually appre- ciated that one single most important parameter is the viral load; the extent of viral load can help explain many clinical observations. Another eye-catching finding was the report of a clinical follow-up of a group of long-term nonpro- gressors. If the underlying operative mechanism can be elucidated, we can learn the necessary elements for halting HIV infection progression. Therapeu- tically, the trend has shifted to combination therapy, preferentially 3-drug combination of 2 RT inhibitors and 1 protease inhibitor. For the vaccine development, many novel vectors were introduced, but their potentials are unknown at present. The successful application of single-cell in situ PCR has changed our perception of HIV infection. This powerful technique can detect a single viral genome inside cells and revealed that a large proportion of cells already harbor HIV genomes soon after the entry of HIV into the body. A direct viral effect may fully explain subsequent T cell depletion without invok- ing a lot of indirect mechanisms such as apoptosis.
- 中文關鍵字: --
- 英文關鍵字: HIV; AIDS; Epidemiology