- 作者: 劉霞,武全香,師彥平
- 作者服務機構: Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
- 中文摘要: A thorough investigation of Cacalia tangutica (Franch.) Hand-Mazz afforded two new epimeric eremophilane sesquiterpenoids, 7b-H-3a-angeloyloxy-9-ene-11,12-epoxy-8-oxoeremophilane (1) and 7a-H-3a-angeloyloxy-9-ene-11,12-epoxy-8-oxoeremophilane (2), as well as four known sesquiterpenes, petasol (3), oplopanone (4), 4,5-epoxy-b-caryophyllene (5), 4(15)-eudesmene-1b,6a-diol (6), and three known monoterpenes, 1b,2a-dihydroxy-p-menth-5-ene (7), 5a-hydroxy-2-oxo-p-menth-6(1)-ene (8), 5b-hydroxy-2-oxo-p-menth-6(1)-ene (9), and two known triterpenes, maniladiol 3-O-palmitate (10), taraxasteryl palmitate (11). The new compounds were characterized by means of spectroscopic methods including 1D, 2D NMR and HRESIMS, and the known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, cytotoxicity against selected cancer cells (HL-60, HO-8910 and A-549) of compounds 1-4, 6, 7, 10 were measured in vitro.
- 英文摘要: --
- 中文關鍵字: Cacalia tangutica; Compositae; Sesquiterpenes; Triterpenes; Monoterpenes.
- 英文關鍵字: --