- 作者: --
- 作者服務機構: Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt
- 中文摘要: The reaction of 3-methylthiazolo[3,2-a]benzimidazole-2-carboxylic acid ethyl ester (1) with hydrazine hydrate gives the hydrazide 2 which reacts with CS2/KOH to afford the potassium salt 3. Treatment of 3 with l-aryl-2-bromoethanones 4a,b afforded the 1,3-thiazoline derivatives 6a,b, respectively, while the reaction of 3 with hydrazine hydrate afforded 1,2,4-triazole-3-thione derivative 9. The reaction of 9 with l-aryl-2-bromoethanones 4a,b and with hydrazonyl chlorides 11a,b gave the 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives 10a,b and 12a,b, respectively. Treatment of hydrazide 2 with phenyl isothiocyanate in refluxing benzene gave the thiosemicarbazide derivative 16. The latter reaction gave 1,3,4-oxadiazole derivative 17 when benzene was replaced by DMF. Cyclization of the thiosemicarbazide derivative 16 with NaOH resulted in the formation of the 1,2,4-triazole-3-thione derivative 18.
- 英文摘要: --
- 中文關鍵字: Thiazolo[3,2-a]benzimidazole; Pyrazoles; 1,3,4-Oxadiazoles; 1,3-Thiazolidines; 1,2,4-Triazoles; 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazines; Hydrazonyl chlorides.
- 英文關鍵字: --